Table 3.
Model estimated pharmacodynamics typical values (t.v.), their corresponding relative standard deviation (CV%) and between subject variation (BSV) after intravenous administration of 1 mg/kg prednisolone succinate and ~1 mg/kg prednisolone per os.
| Parameter | Unit | Neutrophils | Lymphocytes | Cortisol | |||
|---|---|---|---|---|---|---|---|
| t.v. (CV%) | BSV (%) | t.v. (CV%) | BSV (%) | t.v. (CV%) | BSV (%) | ||
| IC50/EC50 | ng/mL | 10 (36.9) | 90.3 | 22.5 (32.6) | 52.3 | 0.04 (50.1) | 197.3 |
| Imax/Emax | – | 1 (5.5) | 5.0 | 1 (14.4) | 35.0 | 1 (1.6) | 4.8 |
| n | – | 0.66 (2.2) | – | 1 (0.07) | – | 1 (0.02) | – |
| R0 | 109/L1 ng/mL2 | 4.81 (7.7) | 23.1 | 1.91 (10.8) | 33.4 | 102 (9.8) | 28.2 |
| kout | 1/h | 0.382 (4.2) | – | 0.232 (3.93) | – | 2.4 (4.4) | – |
IC50/EC50, Imax/Emax, n, R0, and kout are the potency value, efficacy value, sigmoidicity parameter, baseline of response, and elimination-rate constant of response, respectively. 1Unit for Neutrophil/Lymphocyte cell counts. 2Unit for cortisol concentration.