Table 2.
LncRNAs that modulate the response of neuroblastoma to chemotherapy.
| LncRNA | Sample | Cell line | Target/pathway | Function | Kaplan Meier | Ref |
|---|---|---|---|---|---|---|
| NORAD | Human, Mouse |
SK-N-SH, IMR-32, SK-N-SH/DOx, IMR-32/Dox | ATG5, LC3-I/II, P62, Beclin-1, PCNA, Cyclin-D1 Bcl-2, Bax, HDAC8 |
NORAD by upregulating HDAC8 via buffering miR-144-3p could enhance doxorubicin resistance of NB. | Higher expression of NORAD was associated with a lower OS rate. | (53) |
| SNHG7 | Human | HUVEC, LAN-6, SK-N-AS, LAN-6/Cis, SK-N-AS/Cis |
miR-329-3p, MYO10, LC3B-I/II, Beclin-1, P62 | SNHG7 by regulating the miR-329-3p/MYO10 axis could enhance chemoresistance to cisplatin via modulating cisplatin-induced autophagy. | – | (62) |
| SNHG16 | Human, Mouse | SK-N-AS, SK-N-SH, SK-N-AS/Cis, SK-N-SH/Cis |
miR-338-3p, PLK4 MRP-1, p-gp, P13K/AKT |
SNHG16 via regulating miR-338-3p/PLK4 axis could enhance cisplatin resistance in NB. | – | (63) |