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. 2021 Jun 9;11:670917. doi: 10.3389/fonc.2021.670917

Table 2.

LncRNAs that modulate the response of neuroblastoma to chemotherapy.

LncRNA Sample Cell line Target/pathway Function Kaplan Meier Ref
NORAD Human,
Mouse
SK-N-SH, IMR-32, SK-N-SH/DOx, IMR-32/Dox ATG5, LC3-I/II,
P62, Beclin-1,
PCNA, Cyclin-D1
Bcl-2, Bax, HDAC8
NORAD by upregulating HDAC8 via buffering miR-144-3p could enhance doxorubicin resistance of NB. Higher expression of NORAD was associated with a lower OS rate. (53)
SNHG7 Human HUVEC, LAN-6, SK-N-AS,
LAN-6/Cis,
SK-N-AS/Cis
miR-329-3p, MYO10, LC3B-I/II, Beclin-1, P62 SNHG7 by regulating the miR-329-3p/MYO10 axis could enhance chemoresistance to cisplatin via modulating cisplatin-induced autophagy. (62)
SNHG16 Human, Mouse SK-N-AS,
SK-N-SH,
SK-N-AS/Cis,
SK-N-SH/Cis
miR-338-3p, PLK4
MRP-1, p-gp,
P13K/AKT
SNHG16 via regulating miR-338-3p/PLK4 axis could enhance cisplatin resistance in NB. (63)