Table 2.
Clinical characteristics and biochemistries in patients with Gitelman syndrome.
| Patients | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | Mean ± SD | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SBP/DBP (mmHg) | 123/65 | 111/68 | 120/80 | 114/78 | 128/70 | 120/64 | 126/64 | 120/70 | 105/84 | 115/68 | 116.2 ± 7.5/69.7 ± 7.4 | |
| Serum | Reference | |||||||||||
| BUN (mmol/L) | 2.50–8.93 | 5.71 | 5.36 | 7.85 | 4.64 | 6.07 | 5.36 | 7.14 | 4.64 | 4.28 | 5.71 | 5.68 ± 1.12 |
| Creatinine (μmol/L) | 61.9–106.1 | 79.6 | 88.4 | 114.9 | 53 0 | 106.1 | 106.1 | 88.4 | 97.2 | 70.7 | 97.2 | 90.17.0 ± 18.54 |
| Sodium (mmol/L) | 136–145 | 135 | 135 | 138 | 132 | 140 | 142 | 138 | 137 | 134 | 134 | 137.1 ± 3.1 |
| Potassium (mmol/L) | 3.5–5.1 | 2.6 | 1.9 | 2.4 | 2.9 | 2.8 | 2.3 | 2.1 | 2.1 | 1.5 | 2.8 | 2.34 ± 0.45 |
| Chloride (mmol/L) | 98–107 | 97 | 100 | 98 | 94 | 97 | 99 | 97 | 98 | 96 | 96 | 97.2 ± 1.7 |
| Total Calcium (mmol/L) | 2.15–2.55 | 2.33 | 2.20 | 2.33 | 2.35 | 2.53 | 2.45 | 2.50 | 2.23 | 2.45 | 2.45 | 2.38 ± 0.11 |
| Magnesium (mmol/L) | 0.7–1.05 | 0.53 | 0.66 | 0.62 | 0.62 | 0.70 | 0.66 | 0.74 | 0.58 | 0.62 | 0.53 | 0.63 ± 0.67 |
| Hematocrit (%) | 38.0–47.0 | 45.7 | 49.0 | 46.3 | 39.9 | 53.9 | 54.0 | 48.3 | 46.8 | 44.4 | 45.6 | 47.4 ± 4.3 |
| Albumin (g/L) | 35–57 | 43 | 37 | 43 | 48 | 47 | 46 | 43 | 38 | 46 | 45 | 44 ± 4 |
| PRA (ng/ml/hr) | 1.31–3.95 | 17.15 | 10.29 | 47.13 | 6.32 | 50.00 | 31.97 | 38.35 | 29.04 | 30.35 | 29.14 | 28.9 ± 14.4 |
| PAC (pg/ml) | 70–350 | 252 | 206 | 140 | 147 | 134 | 266 | 304 | 320 | 288 | 237 | 229.4 ± 69.6 |
| HCO3− (mmol/L) | 24 | 31.6 | 27.2 | 30.7 | 28.0 | 33.0 | 26.8 | 28.0 | 22.6 | 24.1 | 35.1 | 28.7 ± 3.9 |
| Urine | ||||||||||||
| Creatinine (mmol/L) | 10.6 | 9.4 | 7.9 | 5.7 | 7.3 | 2.1 | 7.9 | 6.2 | 4.7 | 5.2 | 8.6 ± 3.8 | |
| Sodium (mmol/L) | 172 | 53 | 58 | 66 | 64 | 46 | 96 | 32 | 42 | 199 | 82.8 ± 57.1 | |
| Potassium (mmol/L) | 45 | 21 | 27 | 48 | 43 | 26 | 17 | 56 | 37 | 49 | 36.9 ± 13.3 | |
| Chloride (mmol/L) | 143 | 86 | 93 | 67 | 44 | 59 | 51 | 35 | 77 | 207 | 86.2 ± 52.4 | |
| Calcium (mmol/L) | 0.58 | 0.55 | 0.25 | 1.28 | 0.23 | 0.05 | 0.10 | 0.63 | 0.38 | 0.53 | 0.46 ± 0.35 | |
| Magnesium (mmol/L) | 3.09 | 2.55 | 2.34 | 3.58 | 3.17 | 0.86 | 0.62 | 2.26 | 1.52 | 4.61 | 2.46 ± 1.23 | |
| TTKG | 7.15 | 7.28 | 7.10 | 10.80 | 12.51 | 12.61 | 7.13 | 41.13 | 22.67 | 6.23 | 13.46 ± 10.91 | |
SBP, systolic blood pressure; DBP, diastolic blood pressure; PRA, plasma renin activity; PAC, plasma aldosterone concentration; TTKG, transtubular potassium gradient.