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The structures of brevicidines and the predicted biosynthetic gene cluster. (A) The non-ribosomal peptide synthetases genes harbored by the Brevibacillus laterosporus DSM 25 genome. (B) the catalytic domains encoded by the gene cluster, and the substrates incorporated by the respective modules. Domains: A, adenylation; T, thiolation; C, condensation; E, epimerization; TE, thioesterase. (C) structures of brevicidines. The red color indicates the different structure of brevicidines.
