FIGURE 5.

Brevicidines show exceptional low cytotoxicity and hemolytic activity. (A) Human erythrocytes were incubated with brevicidines at concentrations ranging from 2 to 64 mg/L. Their hemolytic activity was assessed by the release of hemoglobin. Cells treated without a tested compound were used as no-lysis control. Cells treated with 10% Triton X-100 were used as complete lysis control. The data are representative of three independent experiments. Correlation analyses were evaluated by Pearson r2, ns: p > 0.05, *p < 0.05, and ***p < 0.001 vs. 10% Triton X-100-treated cells. (B) Cytotoxicity of brevibacillins against HepG2 cells. The data are representative of three independent experiments. Correlation analyses were evaluated by Pearson r2, ns: p > 0.05, *p < 0.05, and ***p < 0.001 vs. Untreated cells.