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. 2021 Jun 9;8:690655. doi: 10.3389/fmolb.2021.690655

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Copyright © 2021 Milanetti, Miotto, Di Rienzo, Nagaraj, Monti, Golbek, Gosti, Roeters, Weidner, Otzen and Ruocco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of a SARS-CoV-2 spike region very similar to the sialic-acid binding site on MERS-CoV spike. (A) From left to right, projected region of the real sialic-acid binding site on MERS-CoV, electrostatic potential surface of the same region and cartoon representation of the MERS-CoV spike protein with the binding site highlighted. (B) Putative sialic-acid binding region on SARS-CoV-2 as predicted by our Zernike-based method. From left to right, the projected region of putative interaction site between SARS-CoV and sialic acid, electrostatic potential surface, and cartoon representation of the SARS-CoV spike protein with the binding site highlighted. (C) Same as (B) but for SARS-CoV spike protein.