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. 2021 Jun 9;8:690655. doi: 10.3389/fmolb.2021.690655

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Copyright © 2021 Milanetti, Miotto, Di Rienzo, Nagaraj, Monti, Golbek, Gosti, Roeters, Weidner, Otzen and Ruocco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sequence and structure comparison of the N-terminal region of MERS-CoV, SARS-CoV-2 and SARS-CoV. (A) A multiple sequence alignment between the MERS-CoV, the SARS-CoV and the SARS-CoV-2 spike protein sequence. (B) Structural comparison between MERS-CoV and SARS-CoV-2 A-domain. The three segments of the sialic-acid binding site for MERS-CoV spike and the proposed binding site on SARS-CoV-2 spike are highlighted. (C) Structural comparison between SARS-CoV and SARS-CoV-2 A-domain. The proposed binding site on SARS-CoV-2 has no corresponding structure in the SARS-CoV spike.