Fig. 3.

Random forest proximity plots for the serum and prostatic tissue hormone profiles. Grey dots represent men who received atorvastatin intervention and white dots represent patients who received placebo. The large grey and white dots are the mean centroids of atorvastatin and placebo arms, respectively. More densely clustered patients demonstrate similar within-group hormone profiles. Fig. 3a) serum profile after intervention shows densely clustered atorvastatin (n = 56) users indicating similarity in their hormone profiles whereas placebo (n = 52) users are randomly scattered indicating that no harmonic changes occurred in placebo arm. Fig. 3b) prostatic tissue profile after intervention does not show as clear clustering amongst atorvastatin (n = 51) users compared to serum hormone profiles, and no clustering of placebo arm (n = 48). The mean centroids are separated which indicates overall difference between the study arms.