Table 5.
Comparison of mean scores of AAS28 items as well as AE-QoL items and domains between bradykinin (BMAE) and mast cell mediated angioedema (MMAE).
| 2nd visit (week 4) | BMAE | MMAE | p |
|---|---|---|---|
| n of patients | n: 31 (33%) mean ± sd (range/median) |
n: 63 (67%) mean ± sd (range/median) |
|
| AAS28 item scores n:61 | |||
| Durationa | 4.6 ± 4.1 (0–19/4) | 7.9 ± 7.6 (0–30/4) | 0.187 |
| Physical discomfort caused | 6.6 ± 5.7 (0–27/5) | 12.3 ± 14.4 (0–63/7) | 0.098 |
| Impact on daily activities | 4.8 ± 4.7 (0–22/4) | 6.0 ± 7.4 (0–28/3) | 0.856 |
| Impact on appearance | 5.8 ± 5.5 (0–27/4.5) | 10.5 ± 13.6 (0–63/6) | 0.156 |
| Overall severity | 6.8 ± 5.8 (0–28/5.5) | 10.9 ± 12.9 (0–58/6) | 0.329 |
| Domains of AE-QoL n:94 | |||
| Functioning | 38.3 ± 21.5 (0–75/43.7) | 24.1 ± 23.8 (0–93.75/18.7) | 0.005 |
| Impairment of work | 1.6 ± 1.1 (0–4/2) | 1.0 ± 1.1 (0–4/1) | 0.01 |
| Impairment of physical activity | 1.6 ± 1.0 (0–3/2) | 1.0 ± 1.1 (0–4/1) | 0.007 |
| Impairment of spare time activities | 1.2 ± 1.0 (0–3/1) | 0.7 ± 1.0 (0–4/0) | 0.033 |
| Impairment of social relations | 1.7 ± 1.1 (0–3/2) | 1.1 ± 1.2 (0–3/1) | 0.012 |
| Fear/shame | 57.1 ± 19.5 (20.8–87.5/62.5) | 42.3 ± 29.9 (0–100/41.7) | 0.01 |
| Feeling burdened at having swellings | 2.2 ± 1.1 (0–4/2) | 1.7 ± 1.3 (0–4/2) | 0.1 |
| Fear of new suddenly appearing swellings | 2.9 ± 0.9 (1–4/3) | 1.9 ± 1.5 (0–4/2) | 0.002 |
| Fear of increased frequency of swellings | 2.7 ± 1.0 (1–4/3) | 2.1 ± 1.4 (0–4/2) | 0.049 |
| Ashamed to visit public places | 1.9 ± 1.3 (0–4/2) | 1.3 ± 1.4 (0–4/1) | 0.028 |
| Embarrassed by the appearance of swellings | 1.7 ± 1.1 (0–4/2) | 1.3 ± 1.4 (0–4/1) | 0.06 |
| Fear of long term negative drug effects | 2.2 ± 1.3 (0–4/2) | 1.8 ± 1.5 (0–4/2) | 0.149 |
| Fatigue/mood | 41.4 ± 21.8 (5–80/40) | 36.42 ± 26.4 (0–95/35) | 0.304 |
| Difficulties of falling asleep | 1.5 ± 1.0 (0–4/2) | 1.3 ± 1.2 (0–4/1) | 0.420 |
| Waking up during the night | 1.7 ± 1.1 (0–4/2) | 1.6 ± 1.3 (0–4/2) | 0.741 |
| Feeling tired during the day | 1.7 ± 1.0 (0–4/2) | 1.6 ± 1.3 (0–4/1) | 0.608 |
| Difficulties in concentrating | 1.7 ± 1.1 (0–4/2) | 1.3 ± 1.2 (0–4/1) | 0.106 |
| Feeling downhearted | 1.7 ± 1.2 (0–4/2) | 1.4 ± .1.3 (0–4/1) | 0.225 |
| Nutrition | 24.2 ± 23.5 (0–75/25) | 26.8 ± 27.8 (0–100/25) | 0.865 |
| General limitations in foods and eating | 1 ± 1.2 (0–4/0) | 0.8 ± 1.1 (0–4/0) | 0.430 |
| Limitations in the selection of food and beverages | 0.9 ± 1.3 (0–4/0) | 1.3 ± 1.4 (0–4/1) | 0.128 |
All p values were assesed by Mann Whitney U test.
Angioedema activity score (AAS), angioedema quality of life questionnaire (AE-QoL), bradykinin cell mediated angioedema (BMAE), mast cell mediated angioedema (MMAE).
a
Swelling duration was scored according to the time period that patients experience the swelling such as; midnight – 8 a.m./8 a.m.–4 p.m./4 p.m. – midnight; each represents 1 points