Table 2.
Gene expression of NTAL and its interactors in AML patients and healthy HSC—BloodSpot and GSE30029 datasets
| Gene name | Description | Log2 expression levels (median, range) |
p Value | |
|---|---|---|---|---|
| Healthy HSC | AML blasts | |||
| NTAL | Linker for activation of T-cells family member 2 | 7.43 (6.71, 8.11) | 7.55 (2.14, 10.1) | 0.105 |
| LAMTOR5 | Ragulator complex protein LAMTOR5 | 9.2 (8.76, 9.45) | 9.84 (6.9, 11.07) | 0.006∗∗ |
| LAMTOR1 | Ragulator complex protein LAMTOR1 | 7.85 (7.05, 8.75) | 8.5 (5.7, 9.7) | 0.051 |
| LAMTOR2 | Ragulator complex protein LAMTOR2 | 6.68 (5.47, 7.4) | 8.09 (5.07, 9.76) | 0.0042∗∗ |
| LAMTOR3 | Ragulator complex protein LAMTOR3 | 5.42 (4.74, 6.54) | 4.34 (2.8, 6.25) | 0.0001∗∗∗ |
| LYN | Tyrosine-protein kinase Lyn | 10.15 (9.73, 10.51) | 10.2 (7.58, 12.24) | 0.460 |
| CD44 | CD44 antigen | 10.3 (8.89, 11.1) | 12.1 (8.26, 14.18) | 0.003∗∗ |
| HCK | Tyrosine-protein kinase HCK | 3.5 (2.69, 3.91) | 7.5 (3.76, 10.3) | 0.001∗∗∗ |
| INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | 9 (7.99, 9.52) | 7.98 (6.3, 12.1) | 0.029∗ |
| YES | Tyrosine-protein kinase Yes | 8.43 (7.1, 9.82) | 6.21 (3.5, 10.18) | 0.001∗∗∗ |
| GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 8.5 (8.28, 9.01) | 10.28 (7.44, 11.13) | 0.001∗∗∗ |
| CHCHD2 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 | 9.26 (8.61, 10.13) | 10.68 (8.4, 11.1) | 0.002∗∗ |
| CD59 | CD59 glycoprotein | 10.33 (9.72, 10.67) | 6.35 (3.15, 10.8) | 0.0001∗∗∗ |
| GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 104 (40.2, 291, 6) | 69.9 (15.4, 178.1) | 0.054 |
| NACA | Nascent polypeptide-associated complex subunit alpha | 13.4 (13.28, 13.49) | 13.2 (11.18, 13.5) | 0.001∗∗∗ |
| RGS19 | Regulator of G protein signaling 19 | 7.47 (7.02, 8.11) | 8.53 (4.8, 9.82) | 0.0007∗∗∗ |
| RFTN1 | Raftlin | 5.64 (3.68, 7.01) | 5.32 (4.8, 5.77) | 0.642 |
| BST2 | Bone marrow stromal antigen 2 | 9.2 (7.62, 9.73) | 7.07 (4.23, 9.8) | 0.002∗∗ |
| GNG2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | 5.16 (2.73, 5.95) | 7.87 (6.19, 11.1) | 0.001∗∗∗ |
| GNAI3 | Guanine nucleotide-binding protein G(k) subunit alpha | 8.9 (8.03, 9.8) | 9.77 (7.77, 11.3) | 0.043∗ |
| PAG1 | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 | 3.5 (2.93, 6.14) | 7.35 (2.5, 10.15) | 0.001∗∗∗ |
| CSK | Tyrosine-protein kinase CSK | 8.2 (7.64, 8.78) | 8.25 (6.19, 9.96) | 0.862 |
| COX5B | Cytochrome C Oxidase Subunit 5B | 8.77 (8.03, 8.95) | 10.05 (6.25, 11.04) | 0.0024∗∗ |
| MARCKS | Myristoylated Alanine Rich Protein Kinase C Substrate | 4.99 (3.85, 5.51) | 8.26 (2.84, 12.22) | 0.0085∗∗ |
| RP2 | RP2 Activator of ARL3 GTPase | 4.62 (4.24, 4.92) | 6.001 (3.48, 8.47) | 0.0001∗∗∗ |
| SSSCA1 | Sjoegren syndrome/scleroderma autoantigen 1 | 6.35 (5.42, 7.03) | 7.12 (4.25, 9.56) | 0.071 |
| TESC | Calcineurin B homologous protein 3 | 4.87 (3.88, 6.32) | 7.01 (4.26, 10.4) | 0.001∗∗∗ |
| GRB2 | Growth factor receptor-bound protein 2 | 8.5 (7.9, 8.98) | 8.85 (6.6, 10.2) | 0.072 |
| PHB | Prohibitin | 8.26 (7.26, 9.48) | 8.12 (4.19, 10.1) | 0.359 |
| GNG7 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 | 6.2 (6.02, 7.07) | 6.32 (4.4, 8.38) | 0.667 |
| LGALS9 | Galectin-9 | 6.5 (6.09, 7.46) | 7.25 (5.56, 8.55) | 0.029∗ |
| LGALS1 | Galectin-1 | 4.48 (3.8, 5.95) | 10.12 (4.7, 12.26) | 0.001∗∗∗ |
| ERLIN2 | Erlin-2 | 7.03 (6.28, 8.41) | 7.01 (4.17, 8.77) | 0.793 |
| FLOT1 | Flotillin-1 | 7.4 (5.92, 8.48) | 8.64 (5.47, 10.99) | 0.020∗ |
| FLOT2 | Flotillin-2 | 6.75 (5.89, 7.11) | 6.95 (5.06, 8.5) | 0.170 |
| HPCAL1 | Hippocalcin-like protein 1 | 6.3 (5.91, 6.49) | 6.2 (4.03, 7.93) | 0.617 |
| PHB2 | Prohibitin-2 | 10.02 (9.53, 10.13) | 10.05 (7.89, 10.84) | 0.974 |
| GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | 8.4 (7.38, 9.34) | 10.05 (8.22, 11.7) | 0.003∗∗ |
| PRNP | Prion Protein | 6.2 (5.35, 7.91) | 7.9 (5.33, 9.88) | 0.001∗∗∗ |
| NDUFA13 | NADH:Ubiquinone Oxidoreductase Subunit A13 | 7.6 (6.7, 8.46) | 9.3 (5.13, 10.58) | 0.0054∗∗ |
| TMEM43 | Transmembrane Protein 43 | 8.31 (7.59, 8.92) | 8.29 (6.08, 10.6) | 0.843 |
| OGDH | Oxoglutarate Dehydrogenase | 5.8 (4.52, 6.36) | 6.18 (4.29, 8.73) | 0.134 |
| GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 8.36 (7.58, 9.74) | 9.95 (6.6, 11.29) | 0.004∗∗ |
| SH3KBP1 | SH3 Domain Containing Kinase Binding Protein 1 | 7.85 (7.1, 8.46) | 8.38 (5.24, 9.67) | 0.0337∗ |
| TMEM173 | Stimulator of interferon genes protein | 8.95 (7.06, 9.72) | 8.66 (4.88, 10.82) | 0.872 |
| PSMD7 | Proteasome 26S Subunit, Non-ATPase 7 | 8.44 (7.66, 8.805) | 8.25 (4.64, 9.01) | 0.3612 |
| LRRFIP1 | LRR Binding FLII Interacting Protein 1 | 11.49 (11.1, 11.75) | 10.73 (8.97, 12.29) | 0.0075∗∗ |
| TIMM50 | Translocase of Inner Mitochondrial Membrane 50 | 6.15 (5.43, 6.95) | 6.81 (3.76, 9.32) | 0.0677 |
| STOML2 | Stomatin Like 2 | 7.44 (7.01, 8.56) | 7.98 (4.52, 9.49) | 0.2702 |
| NSF | N-Ethylmaleimide Sensitive Factor, Vesicle Fusing ATPase | 6.31 (6.12, 6.96) | 5.94 (2.45, 7.49) | 0.0735 |
∗ p > 0.05, ∗∗ p > 0.01, and ∗∗∗ p > 0.001.