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Schematic representation of NET involvement in infectious and noninfectious diseases. NET formation induced by staphylococcal bacteremia and sepsis can cause tissue damage and enhance bacterial permeation of deeper structures in the body. NETosis also has a role in noninfectious disease such as autoimmunity (systemic lupus erythematosus and rheumatoid arthritis), atherosclerosis, vasculitis, and cancer.
