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. 2021 Jun 9;12:679643. doi: 10.3389/fgene.2021.679643

FIGURE 2.

FIGURE 2

LncRNA-MIAT in ADSC-Exos alleviates endometrial fibrosis. (A) Thermal map analysis of the top differentially expressed lncRNAs in endometrial samples from patients with endometrial injury. (B) qPCR analysis of the lncRNA-MIAT expression level in TGF-β1-induced ESC injury. (C) qPCR analysis of the lncRNA-MIAT expression level in TGF-β1-induced ESC injury cocultured with or without ADSC-Exos. (D) Western blot analysis of CK19, TGFβR1, and α-SMA protein expression in TGF-β1-induced ESC injury co-cultured with or without ADSC-Exos. Data are presented as the mean ± SD (n = 3). Two-tailed unpaired Student’s t-test, *P < 0.05; ***P < 0.001; ****P < 0.0001. ADSC-Exos, adipose-derived mesenchymal stem cells-exosome; qPCR, real time quantitative PCR; TGF-β1, transforming growth factor-β1; ESC, endometrial epithelial cells; CK19, cytokeratin 19; TGFβR1, homo sapiens transforming growth factor beta receptor 1; α-SMA, alpha smooth muscle Actin. SD, standard deviation.