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. 2021 Jun 9;12:679643. doi: 10.3389/fgene.2021.679643

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Copyright © 2021 Shao, Qin, Wan, Cheng, Wang, Ai, Cheng and Tong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LncRNA-MIAT in ADSC-Exos alleviates endometrial fibrosis by targeting miR-150. (A) Schematic representation of the miR-150 site in lncRNA-MIAT-3’UTR. (B) Luciferase activity was assayed in TGF-β1-induced ESC injury co-transfected with miR-150 and luciferase reporters containing lncRNA-MIAT-3’UTR. (C) Western blot analysis of CK19, TGFβR1, and α-SMA protein expression in TGF-β1-induced ESC injury co-cultured with or without ADSC-Exos in the absence or presence of miR-150 mimic. Data are presented as the mean ± SD (n = 3). Two-tailed unpaired Student’s t-test, **P < 0.01; ****P < 0.0001. ADSC-Exos, adipose-derived mesenchymal stem cells-exosome; TGF-β1, transforming growth factor-β1; ESC, endometrial epithelial cells; CK19, cytokeratin 19; TGFβR1, Homo sapiens transforming growth factor beta receptor 1; α-SMA, alpha smooth muscle actin. SD, standard deviation.