TABLE 4.
Association of anthropometric trait with the risk of prostate cancer using sex-combined and male-specific instruments.
| Exposure | Sex-combined IVs | Male-specific IVs | u (P) | ||||||
| k0/k1 | PVE (%) | Power (%) | OR (95% CI, P) | k0/k1 | PVE (%) | Power (%) | OR (95% CI, P) | ||
| BMI | 97/60 | 1.12 | 81.3 | 0.865 (0.764∼0.979, 0.022) | 30/22 | 0.77 | 67.7 | 0.862 (0.738∼1.007, 0.060) | 0.190 (0.849) |
| WHR | 39/21 | 0.56 | 59.2 | 0.854 (0.681∼1.071, 0.172) | 3/1 | 0.04 | 5.2 | 1.094 (0.545∼2.198, 0.800) | −0.969 (0.333) |
| WC | 70/50 | 1.02 | 14.1 | 0.954 (0.808∼1.126, 0.577) | 29/21 | 1.15 | 59.0 | 0.895 (0.763∼1.050, 0.175) | 2.688 (0.007) |
| HIP | 89/64 | 1.40 | 5.4 | 1.016 (0.886∼1.166, 0.817) | 31/17 | 0.83 | 28.6 | 1.086 (0.873∼1.350, 0.457) | −1.428 (0.153) |
IV, instrumental variable; BMI, body mass index; WHR, waist-to-hip ratio; WC, waist circumference; HIP, hip circumference; MR, Mendelian randomization; PVE, phenotypic variance explained by IVs that were used in our final MR analysis; power, statistical power; OR, odds ratio; CI, confidence internal.
Note that k0 is the number of candidate instruments, while k1 is the final number of instruments employed in the analysis.