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. 2021 Jun 9;9:668648. doi: 10.3389/fcell.2021.668648

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Copyright © 2021 Tomasello, Distefano, Nigita and Croce.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Examples of isomiRs. MicroRNA isoforms can variate for length, sequence, or both. The current classification identified five classes of variants: (1) canonical microRNAs; (2) 5′ isomiRs; (3) 3′ isomiRs; (4) polymorphic isomiRs; (5) mixed type isomiRs.