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sVEGFR1 release is not PAR-1-dependent. HUVECs were treated with different concentrations of GrK or GrKSA with or without PAR-1 inhibitor ATAP2. IL-6 was used as a positive control for PAR-1 dependent cytokine release after (A) 6h and (B) 24h of incubation. After (C) 6h and (D) 24h of incubation with GrK(SA) no PAR-1 dependent release of sVEGFR1 was seen. Results are depicted as mean ± SEM,n=3. *P < 0.05; ****P <0.0001, compared to its condition without ATAP2.
