Table 3.
Interacting sites of the nsp12-7-8 complex involved in contacts with viral RNA in the absence and presence of drugs.
| (nsp12 to nsp7-8) to RNA | (nsp12 to nsp7-8) with drug to RNA |
||||||||
| IDX_184 | Remdesivir | Ribavirin | Sofosbuvir | ||||||
| Position | Residue | Position | Residue | Position | Residue | Position | Residue | Position | Residue |
| 21 (nsp7) | Arg | 21 (nsp7) | Arg | 21 (nsp7) | Arg | 21 (nsp7) | Arg | 21 (nsp7) | Arg |
| 26 (nsp7) | Ser | 26 (nsp7) | Ser | 26 (nsp7) | Ser | 26 (nsp7) | Ser | 26 (nsp7) | Ser |
| 73 (nsp8) | Gln | 73 (nsp8) | Gln | 73 (nsp8) | Gln | 73 (nsp8) | Gln | 29 (nsp7) | Trp |
| 75 (nsp8) | Arg | 75 (nsp8) | Arg | 75 (nsp8) | Arg | 75 (nsp8) | Arg | 73 (nsp8) | Gln |
| 76 (nsp8) | Ser | 80 (nsp8) | Arg | 80 (nsp8) | Arg | 80 (nsp8) | Arg | 75 (nsp8) | Arg |
| 80 (nsp8) | Arg | 80 (nsp8) | Arg | ||||||
| nsp7-8 complex binds nsp12 on its finger domain (L366-A581 and K621-G679) and thumb domain (H816-Q932) [22] | Galidesivir |
Setrobuvir |
Tenofovir |
YAK |
|||||
| Position | Residue | Position | Residue | Position | Residue | Position | Residue | ||
| 21 (nsp7) | Arg | 21 (nsp7) | Arg | 21 (nsp7) | Arg | 21 (nsp7) | Arg | ||
| 26 (nsp7) | Ser | 26 (nsp7) | Ser | 26 (nsp7) | Ser | 26 (nsp7) | Ser | ||
| 73 (nsp8) | Gln | 73 (nsp8) | Gln | 73 (nsp8) | Gln | 73 (nsp8) | Gln | ||
| 75 (nsp8) | Arg | 75 (nsp8) | Arg | 75 (nsp8) | Arg | 75 (nsp8) | Arg | ||
| 80 (nsp8) | Arg | 80 (nsp8) | Arg | 80 (nsp8) | Arg | 80 (nsp8) | Arg | ||