Parry 1977.

Study characteristics
Methods	Quasi‐RCT (alternate allocation). Parallel trial. Duration: 14 days. Symptomatic regimen.
Participants	28 participants, but some enrolled on multiple occasions giving 42 courses/data sets. Total cohort: 21 male, 21 female, mean age 15.1 years. PsA colonised. 14 participants in each of 3 treatment groups. Group 1 (ticarcillin): 8 male, 6 female; mean (range) age 16.1 (2 ‐ 30) years. Group 2 (ticarcillin & gentamicin): 7 males, 7 females: mean (range) age 16.4 (4 ‐ 30) years. Group 3 (gentamicin): 6 males, 8 females; mean (range) 12.9 (5 ‐ 31) years. This was a control group from the same study period not part of the alternate allocation.
Interventions	Single group 1; ticarcillin 300 mg/kg/day, 4‐hourly. Single group 2: gentamicin 3 ‐ 4 mg/kg/day (adults), 4 ‐ 7 mg/kg/day (children). Combination group: ticarcillin 300 mg/kg/day, 4‐hourly plus gentamicin 3 ‐ 4 mg/kg/day (adults), 4 ‐ 7 mg/kg/day (children). All participants also received chest physiotherapy, bronchial drainage and aerosol therapy with mucolytics.
Outcomes	Lung function, bacteriology, adverse events, CBC, sedimentation rate, urinalysis, serum electrolytes, blood urea nitrogen, creatinine, liver function tests, chest radiographs, blood gas determinations, sputum cultures, change in cough, weight.
Notes	No data available. No withdrawals.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No discussion of how first participant was assigned to which treatment group.
Allocation concealment (selection bias)	High risk	Alternation.
Blinding (performance bias and detection bias) All outcomes	High risk	Drugs administered in different ways so clinicians and participants couldn't be blinded, no discussion of blinding of outcome assessors.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No drop outs or withdrawals.
Selective reporting (reporting bias)	High risk	Paper states that "pulmonary function tests were performed when possible", but no further details or results are given.
Other bias	Low risk	None identified.