Pedersen 1986.

Study characteristics
Methods	RCT. Cross‐over design ‐ 3 months in between treatment arms. Duration: 14‐day course. Elective regimen.
Participants	20 participants; 3 drop outs, 17 completed trial. Age, mean: 12.6 years. Gender split: 10 male, 10 female. PsA colonised.
Interventions	Single antibiotic: ceftazidime 150 mg/kg/day, 8‐hourly. Combination antibiotic: ceftazidime plus tobramycin 10 mg/kg/day, 8‐hourly.
Outcomes	Lung function, inflammatory markers, development of resistant strains.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Described as randomised, but no details of method given.
Allocation concealment (selection bias)	Unclear risk	Not discussed.
Blinding (performance bias and detection bias) All outcomes	Low risk	Both interventions given with same volume and in same way. NJ: described as an open study ‐ so I interpret this to mean no blinding??
Incomplete outcome data (attrition bias) All outcomes	Low risk	3 participants excluded ‐ reasons given (bacteriological resistance developed between treatment arms in 2 participants and a 3rd withdrew on first day of 2nd treatment arm due to nausea).
Selective reporting (reporting bias)	Low risk	Outcomes stated in the methods section reported in the results.
Other bias	Low risk	None identified.