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. 2021 Jun 28;18(6):449–461. doi: 10.11909/j.issn.1671-5411.2021.06.006

Table 2. Baseline demographic and clinical characteristics of patients with non-severe bleeding and severe bleeding in the validation group.

Variables Non-severe bleeding (n = 76) Severe bleeding (n = 25) P-value
Data are presented as means ± SD or n (%). *Presented as median (interquartile range).
Age, yrs 63.0 (60.5−71.5)* 65.0 (63.0−73.0)* 0.051
Male 60 (78.9%) 16 (64.0%) 0.133
Body mass index, kg/m2 26.0 ± 3.4 25.1 ± 2.6 0.198
Hypertension 49 (64.5%) 16 (64.0%) 0.966
Hyperlipidemia 11 (14.5%) 4 (16.0%) 1.000
Diabetes mellitus 24 (31.6%) 9 (36.0%) 0.683
Prior myocardial infarction 13 (17.1%) 5 (20.0%) 0.979
Prior percutaneous coronary intervention 9 (11.8%) 2 (8.0%) 0.869
Stroke 10 (13.2%) 4 (16.0%) 0.982
Aspirin 43 (56.6%) 17 (68.0%) 0.313
Clopidogrel 20 (26.3%) 12 (48.0%) < 0.05
Preoperative laboratory test
 Hemoglobin, g/L 133.4 ± 14.8 132.2 ± 14.1 0.707
 Hematocrit, % 39.7 ± 4.4 38.2 ± 4.0 0.144
 Platelet count, × 109/L 213.2 ± 73.3 205.0 ± 49.8 0.605
 Alanine transaminase, U/L 26.4 (16.2−43.4)* 27.0 (18.4−42.1)* 0.850
 Total bilirubin, μmol/L 11.0 ± 3.9 11.6 ± 5.0 0.498
 Serum creatinine, μmol/L 74.4 ± 18.0 75.0 ± 13.4 0.861
 Prothrombin time, s 11.3 (10.9−11.9)* 11.4 (11.1−11.9)* 0.798
 Activated partial thromboplastin time, s 30.0 ± 2.8 30.0 ± 3.4 0.945
 Fibrinogen, g/L 3.2 (2.8−3.5)* 3.6 (3.0−3.8)* 0.105
Postoperative laboratory test
 Hemoglobin, g/L 114.5 (105.0−125.0)* 111.0 (96.0−125.0)* 0.447
 Hematocrit, % 34.3 ± 4.4 32.9 ± 5.7 0.178
 Platelet count, × 109/L 167.5 ± 44.3 150.6 ± 50.0 0.111
 Alanine transaminase, U/L 24.3 (16.0−44.9)* 38.7 (96.0−125.0)* 0.382
 Total bilirubin, μmol/L 14.7 ± 6.1 17.4 ± 6.1 0.058
 Serum creatinine, μmol/L 75.5 (64.5−93.5)* 81.7 (74.7−91.7)* 0.207
 C-reactive protein, mg/L 17.2 (8.4−43.9)* 23.2 (5.1−124.2)* 0.467
 Cardiac troponin I, ng/mL 1.1 (0.5−1.8)* 1.0 (0.5−2.4)* 0.747
 Creatine kinase-MB isozyme, U/L 27.2 ± 9.3 29.8 ± 10.7 0.245
 Prothrombin time, s 12.7 (12.0−13.3)* 12.8 (12.0−13.9)* 0.447
 Activated partial thromboplastin time, s 28.5 ± 3.6 27.7 ± 3.8 0.353
 Fibrinogen, g/L 2.4 ± 0.5 2.3 ± 0.6 0.390
 N-terminal pro-B-type natriuretic peptide, pg/mL 405.4 ± 199.5 398.2 ± 229.0 0.880
Cell saver transfusion, mL 450.0 (300.0−700.0)* 600.0 (350.0−1150.0)* 0.189
Red blood cells, U 0 0 0.355
Plasma, mL 400.0 (0.0−400.0)* 400.0 (50.0−575.0)* 0.227
Postoperative chest drain loss, mL/24 h 660.0 (610.0−950.0)* 1160.0 (1052.5−1420.0)* < 0.05