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Natural and coded levels of independent variables used in two-level full factorial screening design.
| Factor | Symbol | Factor levels |
|
|---|---|---|---|
| Low (−1) | High (+1) | ||
| Solid-solvent ratio | A | 1:10 | 1:25 |
| Solvent concentration (% acetone, v/v) | B | 50 | 80 |
| Extraction time (min) | C | 10 | 20 |
| Sonication amplitude (%) | D | 50 | 75 |
| Sonication mode (pulse duration: pulse interval (sec)) | E | continuous (0:0) | pulsed (5:5) |
