Fig. 3.

AntiOxCIN₄treatment of fibroblasts from sPD patients decreased Lysotracker red-labeled bodies. A typical image of fibroblasts from sPD patients labeled with Lysotracker red in cells treated with vehicle (CT) or AntiOxCIN₄ (A). Lysotracker red intensity fluorescence of human skin fibroblasts from sPD and their matched-controls was obtained by confocal microscopy and measured using FIJI/ImageJ 1.52p program (B). Each measurement corresponds to one different individual (5 fibroblasts from sPD patients and 5 fibroblasts from respective sex- and age-matched healthy controls). Data was normalized by the control condition (C = 100%). Data are expressed as mean ± SEM of 5 different experiments. Statistical significance was accepted with (^####) p < 0.001 to C vs C + AntiOxCIN₄ or PD vs PD + AntiOxCIN₄. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)