Table 5.

Multivariate Cox proportional-hazards models for TTimDC and OS for IBD and control cohorts

Variable	HR (95% CI)	P value
Endpoint: TTimDC (N=178, E=19)
IBD vs control	7.583 (3.003 to 19.148)	<0.0001
Never smoker vs former	4.075 (1.35 to 12.303)	0.01
Current smoker vs former	6.432 (1.734 to 23.859)	0.005
Prior steroids (yes vs no)	2.807 (1.013 to 7.776)	0.047
Endpoint: OS (N=180, E=113)
IBD vs control	0.894 (0.541 to 1.477)	0.66
1-year increase in age	1.001 (0.986 to 1.016)	0.91
Female vs male	1.439 (0.986 to 2.102)	0.06

N means total sample size; E means total number of events. TTimDC event=immune-mediated diarrhea or colitis, death is considered censor. OS event=death by any cause.