. 2021 Jun 19;69:103453. doi: 10.1016/j.ebiom.2021.103453

Table 1.

GEMMs of DMG.

Model	Technical approach	Incidence	Genotype	Cell of Origin	Reference
GEMM
	RCAS/tv-a
		80% by 3 months	PDGF-B, p16 loss	nestin-expressing NPCs (hindbrain)	[59]
		77% in 1 month	PDGF-B, p53 loss	nestin-expressing NPCs (hindbrain)	[61]
		72% by 3 months	H3.3K27M, p53 loss	nestin-expressing NPCs (hindbrain)	[19]
		95% by 3 months	H3.3K27M, p53 loss, PDGF-B	nestin-expressing NPCs (hindbrain)	[111]
		43% by 3 months	H3.3K27M, p53 loss, PDGF-B	Pax3-expressing NPCs (hindbrain)	[64]
		100% by 1–1.5 months	H3.3K27M, p53 loss, PDGF-B	nestin-expressing NPCs (hindbrain)	[112]
	In utero electroporation
		100% by 4 months	H3.3K27M, p53 loss, PDGFRA, ATRX loss	periventricular NPCs (forebrain/hindbrain)	[113]
		100% by 6–8 months	H3.3K27M, p53 loss	periventricular NPCs (forebrain/hindbrain)	[113]
		100% by 4 months	H3.3K27M, p53 loss, ATRX loss	periventricular NPCs (forebrain/hindbrain)	[113]
		>90% by 1.5–2 months	H3.3K27M, DNp53, PDGFRA^D842V	periventricular NPCs (forebrain)	[114]
		100% by 1 month	H3.3K27M, p53 loss, PDGF-B	periventricular NPCs (hindbrain)	[115]
		100% by 1 month	H3.3WT, p53 loss, PDGF-B	periventricular NPCs (hindbrain)	[115]
		100% by 1 month	H3.3WT, p53 loss, PDGFRA^D842V	hindbrain periventricular NPCs (hindbrain)	[115]
		100% by 1 month	H3.3K27M, p53 loss, PDGFRA^WT	hindbrain periventricular NPCs (hindbrain)	[115]
	Transgenic
		100% by 4 months	H3.3K27M, p53 loss	nestin-expressing NPCs	[113]
		100% by 4 months	H3.3K27M, p53 loss	GFAP-expressing NPCs	[113]
		86% by 3 months	H3.3K27M, p53 loss	nestin-expressing NPCs	[21]
		96% by 3 months	p53 loss, PDGFRA^V544ins	nestin-expressing NPCs	[21]
		80% by 3 months	H3.1K27M, ACVR1^G328V, PIK3CA^H1047R	Olig2-expressing OPCs	[116]
		80% by 3 months	H3.1K27M, ACVR1^G328V	Olig2-expressing OPCs	[116]