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. 2021 Jun 14;28(6):527–559. doi: 10.1089/cmb.2020.0032

Table 2.

Several Limiting Constraints on the Information Relations, with Their Interpretations or Consequences

Constraint Consequence
I12=0 Independent segregation of loci implies linkage equilibrium
Δ3=0 Pairwise dependencies only, Ω = I13 + I23; Δ1=I23I12; Δ2=I13I12
I12=I13=I23=0 Three-way dependence only, Δ3 = Ω; Δ1 = Δ2 = Ω

Keep in mind that these rules apply strictly only to the discrete functions without noise.