Table 2.
Sample Characteristics.
| Discovery Sample | |||||
|---|---|---|---|---|---|
| CN | SCD | MCI | AD | Stats | |
| N | 29 | 19 | 21 | 11 | |
| Age (years) | 69.9 ± 7.8 | 68.4 ± 9.3 | 70.8 ± 7.8 | 66.6 ± 12.9 | n.s. |
| Education (years) | 16.5 ± 2.4 | 16.5 ± 2.4 | 16.3 ± 2.5 | 15.3 ± 2 | n.s. |
| Sex (M/F) | 4/25 | 8/11 | 10/11 | 2/9 | p < 0.05 |
| MoCA (z-score) | −0.2 ± 1.3ǂ§ | −0.4 ± 0.9ǂ§ | −2.3 ± 1*^§ | −6.3 ± 2*^ǂ | p < 0.05E-15 |
| Memory (z-score) | −0.2 ± 0.7ǂ§ | −0.2 ± 0.5ǂ§ | −2.1 ± 0.9*^ | −2.7 ± 1.7*^ | p < 0.05E-9 |
| Attention and Processing Speed (z-score) | −0.1 ± 0.6 | 0.1 ± 0.5 | −0.3 ± 0.7 | −0.1 ± 1.1 | n.s. |
| Mean Frame Displacement | 0.20 ± 0.09 | 0.21 ± 0.10 | 0.23 ± 0.12 | 0.29 ± 0.23 | n.s. |
| Validation Sample | |||||
| CN | SCD | MCI | AD | Stats | |
| N | 26 | 28 | 14 | 13 | |
| Age (years) | 66.4 ± 9.9 | 69.8 ± 11.8 | 75.1 ± 5.8 | 66.2 ± 10.2 | n.s. |
| Education (years) | 16.4 ± 2.3 | 16.5 ± 2.7 | 15.4 ± 2.8 | 15.5 ± 3.2 | n.s. |
| Sex (M/F) | 5/21 | 11/17 | 8/6 | 6/7 | n.s. |
| MoCA (z-score) | 0.1 ± 1ǂ§ | −0.6 ± 1.2ǂ§ | −2 ± 1.5*^§ | −5.5 ± 2.7*^ǂ | p < 0.05E-12 |
| Memory (z-score) | −0.1 ± 0.8ǂ§ | −0.3 ± 0.8ǂ§ | −1.5 ± 0.7*^§ | −3.1 ± 0.5*^ǂ | p < 0.05E-7 |
| Attention and Processing Speed (z-score) | −0.3 ± 0.5 | −0.0 ± 0.6 | −0.35 ± 0.7 | −0.2 ± 0.5 | n.s. |
| Mean Frame Displacement | 0.20 ± 0.08 | 0.21 ± 0.10 | 0.23 ± 0.12 | 0.29 ± 0.23 | n.s. |
Data are shown as mean ± standard deviation. P-values represent significance for a one-way analysis of variance or Χ2-test where appropriate. For distributions of sex see Supplementary Fig. 1. CN: Cognitively Normal; SCD: Subjective Cognitive Decline; MCI: Mild Cognitive Impairment; AD: Alzheimer’s disease; n.s.: non-significant; MoCA: Montreal Cognitive Assessment; M: Male; F: Female. The following denote significant pairwise difference in post-hoc t-tests: * significantly different from CN; ^ significantly different from SCD; ǂ significantly different from MCI; § significantly different from AD.