Figure 2.

Clinical course with all treatment regimens. (A) After two sessions of TACE, most of the treated intrahepatic tumor was necrotic. (B) At 1.5 years post-diagnosis, new intrahepatic metastatic lesions 20 mm in size appeared in S7, and (C) multiple metastases 10 mm in size appeared in the spleen during regorafenib treatment. (D) At 2.5 years post-diagnosis, the S7 lesion progressed in the early arterial phase, and the tumor size increased during lenvatinib treatment. Viable tumor growth was also observed around the primary tumor in the posterior segment. Red arrows indicate the primary lesion in the liver, yellow arrows indicate other intrahepatic metastases, and blue arrows indicate splenic metastases. TACE, transcatheter arterial chemoembolization; DEB, drug-eluting beads; C, conventional; DCP, des-γ-carboxy prothrombin; AFP, α-fetoprotein.