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. 2021 Jun 23;9:113. doi: 10.1186/s40478-021-01215-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Autopsy findings. a Lobulated brainstem tumor. b Pons with solid and infiltrative tumor growth. c. Leptomeningeal spread (arrow) at the level of mamillary bodies and infiltrative neoplastic cells in the ventral thalamus as indicated by the square (see f). d, e. Solid well-circumscribed nodule of ependymal differentiation with true ependymal rosettes in the pons (H&E, D:40× , E:600×). f. Infiltrative tumor involving the thalamus, H&E, 400× . g Infiltrative tumor involving the cerebellar dentate nucleus, H&E, 100× . h EMA staining in solid and infiltrative components, 200× . i. H3K27me3 staining is lost in the infiltrative neoplastic cells while retained in the entrapped neurons and endothelial cells, 400× .j. EZHIP (CXorf67) staining highlights the infiltrative component while negative in the endothelial cells and the entrapped neurons 400×