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. 2021 Jun 23;21:723. doi: 10.1186/s12885-021-08456-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — PPI network and hub genes identification. (A) The PPI network of DEGs was constructed by Cytoscape. Red nodes indicate up-regulated genes, green nodes indicate down-regulated genes, the node size is indicative of the degree of connectivity, and line thickness represents combined score. (B-C) The top five hub genes evaluated by cytoHubba and ranked by MCC. The intensity of red color indicated ranking. PPI, protein–protein interaction; MCC, maximal clique centrality