Table 6.
Baseline characteristics, clinical presentation, and outcome of patients with K. pneumoniae liver abscess with or without metastatic infections
| Characteristic | Total n = 135 |
KPLA with Metastatic infection n = 12 |
KPLA without Metastatic infection n = 123 |
P value |
|---|---|---|---|---|
| Age (year) | 60.9 ± 12.7 | 58.3 ± 12.2 | 61.1 ± 12.8 | 0.467 |
| Gender | 0.494 | |||
| Male,n(%) | 80 (59.3) | 6 (50.0) | 74 (60.2) | |
| Female,n(%) | 55 (40.7) | 6 (50.0) | 49 (39.8) | |
| Symptoms | ||||
| Body temperature (≥38.5 °C) | 80 (59.3) | 7 (58.3) | 73 (59.3) | 0.945 |
| Fever | 123 (91.1) | 11 (91.7) | 112 (91.1) | 1.000a |
| Chills | 81 (60.0) | 8 (66.7) | 73 (59.3) | 0.621 |
| Abdominal pain | 58 (43.0) | 6 (50.0) | 52 (42.3) | 0.606 |
| Nausea | 17 (12.6) | 2 (16.7) | 15 (12.2) | 0.648a |
| Vomiting | 16 (11.9) | 2 (16.7) | 14 (11.4) | 0.635a |
| Frailty | 24 (17.8) | 2 (16.7) | 22 (17.9) | 1.000a |
| Diarrhea | 9 (6.7) | 0 | 9 (7.3) | 1.000a |
| Underlying conditions | ||||
| Diabetes mellitus | 67 (50.0) | 7 (58.3) | 60 (48.8) | 0.528 |
| Hypertension | 51 (37.8) | 6 (50.0) | 45 (36.6) | 0.360 |
| Fatty liver | 16 (11.9) | 1 (8.3) | 15 (12.2) | 1.000a |
| Cholelithiasis | 29 (21.5) | 1 (8.3) | 28 (22.8) | 0.461a |
| Viral hepatitis | 32 (23.7) | 2 (16.7) | 30 (24.4) | 0.731a |
| Cardiovascular diseases | 25 (18.5) | 3 (25.0) | 22 (17.9) | 0.696a |
| Chronic renal insufficiency | 14 (10.4) | 5 (41.7) | 9 (7.3) | 0.000 |
| Hepatic dysfunction | 21 (15.6) | 3 (25.0) | 18 (14.6) | 0.399a |
| Abdominal surgery history | 9 (6.7) | 1 (8.3) | 8 (6.5) | 0.579a |
| Abscess location | ||||
| Right lobe | 90 (66.7) | 10 (83.3) | 80 (65.0) | 0.199 |
| Left lobe | 34 (25.2) | 2 (16.7) | 32 (26.0) | 0.730a |
| Both lobes | 11 (8.1) | 0 | 11 (8.9) | 0.598a |
| Laboratory findings | ||||
| WBC > 9.5× 109/L | 105 (77.8) | 10 (83.3) | 95 (77.2) | 0.628 |
| NE% > 75% | 119 (88.1) | 12 (100.0) | 107 (87.0) | 0.359a |
| PLT < 125 | 38 (28.1) | 7 (58.3) | 31 (25.2) | 0.015 |
| Hb < 110 g/L | 37 (27.4) | 2 (16.7) | 35 (28.5) | 0.511a |
| CRP > 10 mg/L | 127 (94.1) | 12 (100.0) | 105 (85.4) | 0.367a |
| PCT > 0.5 ng/ml | 120 (88.9) | 12 (100.0) | 108 (87.8) | 0.360a |
| ALT > 50 U/L | 73 (54.1) | 5 (41.7) | 68 (55.3) | 0.366 |
| AST > 40 U/L | 79 (58.5) | 7 (58.3) | 72 (58.5) | 0.989 |
| ALP > 125 U/L | 100 (74.1) | 10 (83.3) | 90 (73.2) | 0.443 |
| GGT > 60 U/L | 105 (77.8) | 8 (66.7) | 97 (78.9) | 0.332 |
| T.Bil > 20.5 μmol/L | 44 (32.6) | 7 (58.3) | 37 (30.3) | 0.049 |
| ALB< 40 g/L | 129 (95.6) | 12 (100.0) | 117 (95.1) | 1.000a |
| FIB> 4 g/L | 128 (94.8) | 11 (91.7) | 117 (95.1) | 0.487a |
| APTT> 42 s | 80 (59.3) | 6 (50.0) | 74 (60.2) | 0.494 |
| BUN > 7.2 mmol/L | 41 (30.4) | 8 (66.7) | 32 (26.2) | 0.003 |
| Cr > 97 μmol/L | 20 (14.8) | 5 (41.7) | 15 (12.3) | 0.006 |
| Treatment | 0.075 | |||
| Antibiotics alone | 7 (5.2) | 0 | 7 (5.7) | |
| Antibiotics+Percutaneous drainage | 122 (90.4) | 10 (83.3) | 112 (91.1) | |
| Antibiotics+Surgical drainage | 6 (4.4) | 2 (16.7) | 4 (3.3) | |
| Clinical outcomes | 0.007a | |||
| Cured | 133 (98.5) | 10 (83.3) | 123 (100.0) | |
| Poor prognosis | 2 (1.5) | 2 (16.7) | 0 | |