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. 2021 Jun 23;40:205. doi: 10.1186/s13046-021-02015-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — CARMN inhibits proliferation and sensitizes cisplatin in TNBC cells in vitro and in vivo. A Overexpression efficiency of CARMN confirmed by RT-qPCR. B Influence of CARMN overexpression on cell proliferation in TNBC cells detected by CCK8 assay. C Influence of CARMN overexpression on cell colony formation in TNBC cell. D Influence of CARMN overexpression on cell migration detected by transwell assays. E Effect of CARMN overexpression on sensitivity to cisplatin in TNBC cells reflected by relative activity of cells treated with different cisplatin concentration. F Cell apoptosis induced by cisplatin in TNBC cells overexpressing CARMN or control cells. G, H Xenograft tumors of 4 groups: CARMN overexpressed MDA-MB-468 cells + cisplatin; CARMN overexpressed MDA-MB-468 cells + saline; control MDA-MB-468 cells + cisplatin; control MDA-MB-468 + saline. G shows photos of xenograft tumors; H reflects volume and weight of xenograft tumors respectively. Scale bar = 1 cm. I HE staining and expression of Ki67 and PCNA in xenograft tumors with different expression of CARMN. Scale bar = 100 μm. J TUNEL assay of 4 groups of xenografts described above. Scale bar = 200 μm. IC50, 50% inhibition concentration; cDDP: cisplatin. Error bars represent means ± SD, *P < 0.05, **P < 0.01, ***P < 0.001