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. 2021 Jun 23;40:205. doi: 10.1186/s13046-021-02015-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — CARMN is related with cisplatin resistance and cancer related pathways in TNBC and dysregulates MCM5. A Heat map showing 638 differentially expressed genes (DEGs) according to RNA-seq of CARMN overexpressed MDA-MB-231 cells comparing with control cells. B Mapplot of KEGG pathway enrichment analysis of DEGs. Size of the dots represents number of DEGs enriched in each pathway and color of the dots represents p value of the pathways. C GO annotation in biological process enriched of DEGs. D GSEA enrichment analysis of CARMN regulated genes according to RNA-seq. E Correlation between CARMN and DNA replication and cell cycle related genes in TNBC of TCGA dataset. Positions lack of dots represent no statistically significant correlation between two genes. Color and size of dots represents correlation coefficient and larger dots represents higher correlation coefficient between two genes. F DNA replication related DEGs screened by RNA-seq were confirmed by RT-qPCR. G The effect of CARMN in MCM5 protein expression confirmed by Western Blot. EMT: epithelial-mesenchymal transition; cDDP: cisplatin. Error bars represent means ± SD, *P < 0.05, **P < 0.01, ***P < 0.001