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. 2021 Jun 23;40:205. doi: 10.1186/s13046-021-02015-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — CARMN is host gene of miR143-3p which inhibits TNBC cell proliferation and promotes cisplatin sensitivity. A MiR143-3p is transcribed from exon5 of CARMN. Left panel shows the location of embedded miR143-3p in CARMN transcript unit. Right panel shows sequence of pre-miR143 (underline) and miR143-3p (red) embedded in sequence of CARMN exon5. B Correlation among miR143-3p, MCM5 and CARMN expression in TCGA TNBC samples. C Changes of miR143-3p expression in CARMN overexpression cells. D Efficiency of miR143-3p inhibitor in TNBC cells with or without CARMN overexpression. D Influence of CARMN exon5 overexpression on expression of miR143-3p confirmed with RT-qPCR. E Influence of miR143-3p inhibition on cell proliferation of CARMN overexpressed cells and control cells. F Influence of miR143-3p suppression on colony formation of CARMN overexpressed cells and control cells. G Effect of miR143-3p inhibition on sensitivity to cisplatin in CARMN overexpressed cells and control cells. H Effect of miR143-3p inhibition on cell apoptosis assays of CARMN overexpressed cells and control cells treated with cisplatin. CARMN oe: CARMN overexpression; cDDP: cisplatin; IC50, 50% inhibition concentration. Error bars represent means ± SD.*P < 0.05, **P < 0.01, ***P < 0.001