Fig. 5.

Anticancer activity of FeSiNTs/siSPAG5 in a T24 subcutaneous bladder cancer mouse model. A Intratumoral injection of each sample was performed every week in a subcutaneous xenograft model. B Tumor volumes, C tumor Weight, and D the average body weight for 44 days were monitored every 4 days. The tumor volumes were calculated using V = (length) × (width) ²/2 (mean ± SD, n = 5 mice per group). E Representative images of T24 tumor xenografts from the five different mice at day 44. F Kaplan–Meier survival plot of tumor-containing mice; dotted lines represent dose administration time points. ***P < 0.001