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. 2021 Jun 23;19:189. doi: 10.1186/s12951-021-00935-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Illustration of the formation of FeSiNTs/siSPAG5 nanomedicine and active targeting, and combinational RNAi therapy in bladder cancer. The FeSiNTs/siSPAG5 complex protects the SPAG5 siRNA from serum degradation by nucleases and clearance through the kidneys, and promotes SPAG5 siRNA accumulation in tumor cells, thereby silencing SPAG5 in bladder tumors. Downregulated SPAG5 expression inhibits bladder cancer growth and progression