Table 1.

All chemical structures of evaluated compounds and their IC₅₀ values regarding α-amylase and lipase inhibitory activities

Structure	Compound code	R1	R2	R3	IC50 (µg/ml)
					α-amylase	Lipase
	3a	Cl	H	H	2.52 ± 1.1	145.49 ± 2.5
	3b	H	H	H	61.45 ± 1.5	> 400
	3c	I	H	H	39.85 ± 1.3	> 400
	3d	H	I	H	16.36 ± 0.75	118.86 ± 2.1
	3e	Br	H	H	2.57 ± 0.90	78.37 ± 1.72
	3f	H	Br	H	9.29 ± 1.4	> 400
	3 g	Cl	H	Cl	3.94 ± 2.01	> 400
	4a	Cl	H	H	8.88 ± 2.10	> 400
	4b	H	Cl	H	1.25 ± 1.01	> 400
	4c	H	H	H	4.12 ± 1.63	213.82 ± 2.1
	4d	I	H	H	7.95 ± 1.15	187.7 ± 1.23
	4e	H	I	H	3.85 ± 0.98	201.2 ± 2.37
	4f	Br	H	H	1.11 ± 1.07	290.7 ± 2.23
	4 g	H	Br	H	4.90 ± 2.21	225.8 ± 1.43
	4 h	Cl	H	Cl	9.50 ± 0.56	206.6 ± 1.96
	6a	O–CH3	O–CH3	H	8.547 ± 1.55	44.47 ± 2.30
	6b	O–CH3	H	O–CH3	4.286 ± 1.01	100.8 ± 1.73
Acarbose					6.47 ± 2.01	-
Orlistat					–	25.01 ± 1.71