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. 2021 Jun 22;21:722. doi: 10.1186/s12885-021-08499-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — PC enhances the aggressiveness of TC cells by reprogramming fatty acid metabolism. A Western blot analysis of PC and SREBP1c protein expression in different 8505C cells (PC-WT, PC-sh, and PC-sh + SREBP1c-OE); the full blot is provided in the supplementary file. B The CCK-8 assay was used to detect the proliferation of the indicated 8505C cells. C Transwell invasion and metastasis assays were applied to assess the motility of different 8505C cells with a 40× objective lens. ^* p < 0.05; ^*** p < 0.01. The number of invaded cells is shown in histograms on the right. D Tumor growth was monitored in the indicated 8505C cells, and explanted tumor images from sacrificed mice are shown. ^* p < 0.05; ^*** p < 0.01. The number of invaded cells is shown in histograms on the right. Note: OE (overexpression), CCK-8 (Cell Counting Kit-8)