Table 1.

Inclusion and exclusion criteria for general practitioners and patients in the OPTICA trial^a

General practitioners		Patients
Inclusion criteria	Exclusion criteria	Inclusion criteria	Exclusion criteria
- Be a practicing GP in Switzerland - Complete online GCP training - Work with electronic medical records that are compatible with FIRE projectb	- Non participation in the FIRE project -Another GP from the same practice already participating in the trial	- Be a patient of one of the participating GPs - Regularly see his/her GP, who is their main prescriber - ≥ 65 years or older - ≥ 3 chronic conditions - ≥ 5 chronic medications	-Participation in another clinical trial -Written informed consent not obtained from patient or from relative in case of cognitive impairment of the patient

Abbreviations: GCP Good Clinical Practice, FIRE Family medicine ICPC Research using Electronic medical records, OPTICA Optimising PharmacoTherapy In the multimorbid elderly in primary CAre, GP General practitioner

^aAs specified in: Jungo KT, Rozsnyai Z, Mantelli S, et al. ‘Optimising PharmacoTherapy In the multimorbid elderly in primary CAre’ (OPTICA) to improve medication appropriateness: study protocol of a cluster randomised controlled trial. BMJ Open 2019;9:e031080. https://doi.org/10.1136/bmjopen-2019-031080

^bThe FIRE project is a Swiss database with anonymized data from electronic health records of participating GPs. For the purpose of the OPTICA trial, we collect some relevant information for the trial through the FIRE project database, which is why the participation to the FIRE project has to be possible throughout the trial