Table 3.
Summary of the OARs dosimetry parameters of the reoptimized treatment plans (Plan_FD and Plan_UIH) and the original clinical treatment plans (Plan_Manual). All of the values are reported as the mean ± standard deviation
| Site | Structure | Dose-volume metrics | Plan | Value | Comparison (paired t test) |
|---|---|---|---|---|---|
| Rectal | Bladder | V40 (%) | Manual | 43.45 ± 26.96 | – |
| FD | 43.73 ± 26.28 | p = 0.93 | |||
| UIH | 41.76 ± 26.55 | p = 0.14 | |||
| Dmean (cGy) | Manual | 3476 ± 1281 | – | ||
| FD | 3464 ± 1264 | p = 0.82 | |||
| UIH | 3427 ± 1262 | p = 0.25 | |||
| Femoral head_L | Dmean (cGy) | Manual | 2199 ± 773 | – | |
| FD | 2160 ± 718 | p = 0.60 | |||
| UIH | 2185 ± 824 | p = 0.90 | |||
| Femoral head_R | Dmean (cGy) | Manual | 2130 ± 755 | – | |
| FD | 2085 ± 712 | p = 0.41 | |||
| UIH | 2153 ± 819 | p = 0.79 | |||
| NPC | Eye_L | Dmax (cGy) | Manual | 2199 ± 1175 | – |
| FD | 2135 ± 1265 | p = 0.56 | |||
| UIH | 2153 ± 1168 | p = 0.71 | |||
| Eye_R | Dmax (cGy) | Manual | 2441 ± 1892 | – | |
| FD | 2386 ± 1906 | p = 0.61 | |||
| UIH | 2463 ± 1906 | p = 0.88 | |||
| Spinal cord | Dmax (cGy) | Manual | 4261 ± 161 | – | |
| FD | 4227 ± 191 | p = 0.18 | |||
| UIH | 4251 ± 281 | p = 0.86 | |||
| Brainstem | Dmax (cGy) | Manual | 5578 ± 803 | – | |
| FD | 5528 ± 717 | p = 0.43 | |||
| UIH | 5551 ± 706 | p = 0.72 | |||
| Parotid_L | V30 (%) | Manual | 57.78 ± 25.86 | – | |
| FD | 58.07 ± 26.73 | p = 0.82 | |||
| UIH | 57.37 ± 26.36 | p = 0.77 | |||
| Dmean (cGy) | Manual | 4365 ± 926 | – | ||
| FD | 4381 ± 959 | p = 0.65 | |||
| UIH | 4307 ± 951 | p = 0.33 | |||
| Parotid_R | V30 (%) | Manual | 55.53 ± 23.68 | – | |
| FD | 55.16 ± 23.82 | p = 0.78 | |||
| UIH | 53.96 ± 24.88 | p = 0.52 | |||
| Dmean (cGy) | Manual | 4060 ± 508 | – | ||
| FD | 4057 ± 538 | p = 0.95 | |||
| UIH | 3936 ± 608 | p = 0.15 | |||
| Len_L | Dmax (cGy) | Manual | 592 ± 390 | – | |
| FD | 591 ± 387 | p = 0.84 | |||
| UIH | 588 ± 379 | p = 0.68 | |||
| Len_R | Dmax (cGy) | Manual | 568 ± 385 | – | |
| FD | 529 ± 279 | p = 0.34 | |||
| UIH | 529 ± 281 | p = 0.36 | |||
| Optic nerve_L | Dmax (cGy) | Manual | 3551 ± 2224 | – | |
| FD | 3493 ± 2276 | p = 0.32 | |||
| UIH | 3525 ± 2206 | p = 0.69 | |||
| Optic nerve_R | Dmax (cGy) | Manual | 3612 ± 2115 | – | |
| FD | 3617 ± 2119 | p = 0.94 | |||
| UIH | 3784 ± 2113 | p = 0.21 | |||
| Temporal lobe_L | Dmax (cGy) | Manual | 6376 ± 2126 | – | |
| FD | 6444 ± 2156 | p = 0.05 | |||
| UIH | 6397 ± 2125 | p = 0.62 | |||
| Temporal lobe_R | Dmax (cGy) | Manual | 6430 ± 2143 | – | |
| FD | 6442 ± 2130 | p = 0.76 | |||
| UIH | 6390 ± 2123 | p = 0.27 | |||
| Oral cavity | Dmean (cGy) | Manual | 3933 ± 551 | – | |
| FD | 3928 ± 566 | p = 0.73 | |||
| UIH | 3895 ± 565 | p = 0.12 | |||
| Larynx | Dmean (cGy) | Manual | 3829 ± 153 | – | |
| FD | 3809 ± 169 | p = 0.46 | |||
| UIH | 3798 ± 195 | p = 0.28 |