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. 2021 Jun 4;8:675179. doi: 10.3389/fmolb.2021.675179

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Copyright © 2021 Du, Nai, Shen, Li, Huang, Han, Wang, Pang and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-21 affects the proportion of different CAR-T cell subtypes. (A,B) Differentiated subtypes of HER-2 CAR-T cells were measured with surface expression of CD45RA and CCR7 on day 12 after transduction by flow cytometry. Tn:CD45RA + CCR7+, Tcm:CD45RA-CCR7+, Effector memory T cells (Tem): CD45RA-CCR7−, Effector T cells (Te): CD45RA + CCR7−, Results from flow plots of one representative donor and summary data for indicated CAR-T cell groups were shown. (C,D) CAR expression of different cell phenotypes was shown with percentage of CAR⁺ cells out of the corresponding subtypes. Error bars represent ±SEM. Statistical significance was tested using Student’s t-test (*p < 0.05, **p < 0.01, ***p < 0.001).