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IL-12 family cytokine signaling. (A) The IL-12 family cytokine receptors signal through different STAT family members to exert proinflammatory or inhibitory functions. (B) IL-12 expressing CAR T cells can stimulate IL-12 responsive CAR T cells and endogenous T and NK cells. Downstream mediators of IL-12, such as IFNγ, can act on macrophages and dendritic cells to stimulate innate and adaptive immunity.
