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Systemic toxicity in tumor-bearing mice treated with saline, free TPL, blank NPs, TPL/NPs (L), and TPL/NPs (H). a Histopathological changes in heart, liver, spleen, and kidney tissues. Note: poor cytoplasm and light staining (black arrow), nucleus pyknosis and deep staining (green arrow), fat vacuoles (yellow arrow), inflammatory cell infiltration (blue arrow). b Levels of ALT, AST, BUN, and Cr in mouse serum at the therapeutic end point of different treatments. Note: *p < 0.05
