Table 2.
Comparisons for effects of hormonal contraceptives on depressive symptoms
| Desogestrel (75 μg) | |||||||||
| 0.09‡ (−0.88 to 1.07) | Oestradiol/dienogest (3;2;2;1 mg/0;2;3;0 mg) | ||||||||
| 0.06‡ (−0.75 to 0.94) | −0.04‡ (−0.71 to 0.72) | Oestradiol/nomegestrol acetate (1.5 mg/2.5 mg) | |||||||
| 0.04‡ (−0.54 to 0.62) | −0.05‡ (−0.91 to 0.80) | −0.02‡ (−0.76 to 0.66) | Ethinylestradiol/etonogestrel (15 μg/120 μg) | ||||||
| −0.03‡ (−0.61 to 0.55) | −0.13‡ (−1.00 to 0.74) | −0.10‡ (−0.85 to 0.60) | −0.08‡ (−0.61 to 0.46) | Ethinylestradiol/desogestrel (20 μg/150 μg) | |||||
| −0.04‡ (−0.74 to 0.66) | −0.14‡ (−0.96 to 0.69) | −0.11‡ (−0.81 to 0.55) | −0.09‡ (−0.71 to 0.55) | −0.01‡ (−0.47 to 0.46) | Ethinylestradiol/levonorgestrel (20 μg/100 μg) | ||||
| 0.07‡ (−0.71 to 0.85) | −0.02‡ (−0.68 to 0.62) | 0.03‡ (−0.44 to 0.37) | 0.03‡ (−0.59 to 0.64) | 0.11‡ (−0.56 to 0.76) | 0.12‡ (−0.52 to 0.74) | Ethinylestradiol/drospirenone (30 μg/3 mg) | |||
| 0.18‡ (−0.62 to 0.98) | 0.08‡ (−0.47 to 0.63) | 0.12‡ (−0.37 to 0.53) | 0.13‡ (−0.52 to 0.80) | 0.21‡ (−0.46 to 0.88) | 0.22‡ (−0.40 to 0.84) | 0.10‡ (−0.22 to 0.45) | Ethinylestradiol/levonorgestrel (30 μg/150 μg) | ||
| −0.12‡ (−1.00 to 0.74) | −0.22‡ (−0.91 to 0.46) | −0.18‡ (−0.79 to 0.35) | −0.17‡ (−0.92 to 0.58) | −0.09‡ (−0.85 to 0.65) | −0.08‡ (−0.79 to 0.61) | −0.19‡ (−0.70 to 0.31) | −0.30‡ (−0.71 to 0.10) | Levonorgestrel (30 μg) | |
| 0.01‡ (−0.77 to 0.81) | −0.09‡ (−0.70 to 0.54) | −0.05‡ (−0.51 to 0.35) | −0.04‡ (−0.68 to 0.63) | 0.04‡ (−0.60 to 0.69) | 0.05‡ (−0.52 to 0.63) | −0.07‡ (−0.44 to 0.34) | −0.17‡ (−0.46 to 0.13) | 0.13‡ (−0.28 to 0.56) | Placebo |
Data are standardised mean differences (SMD) with 95% credible intervals in the column-defining intervention compared with the row-defining intervention. Higher SMD values correspond with fewer depressive symptoms in the column-defining hormonal contraceptive. None of the results were significant and all evidence was of low certainty (marked with ‡). Ethinylestradiol/dienogest (3;2;2;1 mg/0;2;3;0 mg) is a multiphasic combined oral contraceptive that has four different dosages of hormones throughout a 4-week cycle. The dosages before the ‘slash’ refer to the different dosages of ethinylestradiol, and the ones after the ‘slash’ refer to those of dienogest.