Table 2.
Overview of performance of diagnostic tests in CAPA
| Country | # of CAPA cases | BAL (#positive/#performed) | Aspergillus species | TA/BA (#positive/#performed) | Serum (#positive/#performed) | References |
|---|---|---|---|---|---|---|
| France | 9 |
Culture 5/7 GM 2/7 PCR 3/7 |
A. fumigatus (7) |
Culture 2/2 GM – PCR 2/ 2 |
GM 1/9 BDG 4/8 |
[15] |
| Germany | 5 |
Culture 1/3 GM 3/3 PCR 3/3 |
A. fumigatus (4) |
Culture 2/3 GM ND PCR 1/2 |
GM 2/5 BDG – |
[16] |
| Netherlands | 6 |
Culture 2/3 GM 3/3 PCR – |
A. fumigatus (5) |
Culture 3/3 GM– PCR – |
GM 0/3 BDG – |
[17] |
| Belgium | 6 |
Culture 5/6 GM 5/6 PCR – |
A. fumigatus (5), A. flavus (1) |
Culture – GM– PCR – |
GM 1/5 BDG – |
[18] |
| Italy | 30 |
Culture 19/30 GM 30/30 PCR 20 /30 |
A. fumigatus (16), A. niger (3), A. flavus (1) |
Culture – GM—PCR – |
GM 1/30 BDG – |
[19] |
| UK | 19 |
Only NBL performed; Denominator not reported |
A. fumigatus (9), A. versicolor (1) | Denominator not reported | Denominator not reported | [20] |
| Belgium | 4 |
Culture 4/4a GM 4/4 PCR 2/2 |
Not specified |
GM – BDG - |
[21] | |
| Switzerland | 3 |
Culture – GM– PCR – |
A. fumigatus (3) |
Culture 3/3 GM – PCR 1/? |
GM 1/? BDG 1/? |
[22] |
| France | 19 |
Culture 7/9 GM 7/9 PCR – |
A. fumigatus (14), A. calidoustus (1), A. niger (1) |
Culture 9/10 GM– PCR – |
GM 1/12 BDG – |
[23] |
| Pakistan | 5 | Not specified | A. fumigatus (1), A. flavus (4), A. niger (1) | Not specified |
GM 0/5 BDG 1/5 |
[24] |
| USA | 4 | Not specified | A. fumigatus (4) | Not specified |
GM 1/3 BDG – |
[25] |
| France | 7 |
Culture not specified/5 GM 3/5 PCR 2/5 |
A. fumigatus (5) | Not specified |
GM 1/7 BDG 2/7 |
[26] |
| Netherlands | 8 |
Culture 7/7 GM 2/6 PCR 4/5 |
A. fumigatus (7) |
Culture 1/1 GM 1/1 PCR 1/1 |
GM 0/1 | [27] |
| Netherlands | 11 |
Culture 5/40 GM 11/37 PCR 11/40 |
A. fumigatus (3) |
Culture 3/47 GM not performed PCR 23/30 |
GM 0/11 | [28] |
| USA | 20 |
Culture 2/20 GM 2/20 PCR not specified |
Not specified | Not specified |
GM 8/20 BDG 6/20 |
[29] |
BAL: bronchoalveolar lavage; GM: galactomannan; BDG: beta-D-glucan; PCR: polymerase chain reaction
aBAL and BA were not distinguished