Skip to main content
. 2021 Jun 23;47(8):819–834. doi: 10.1007/s00134-021-06449-4
Recommendations Strength of recommendation Quality of evidence
A CAPA diagnostic work-up is recommended in mechanically ventilated COVID-19 patients with unexplained respiratory deterioration or a positive Aspergillus culture from the respiratory tract Strong Low
Standard CT imaging is not recommended to refute or diagnose CAPA Weak Very low
Screening of critically ill COVID-19 patients for serum GM or BDG is not recommended Strong Low
Detection of Aspergillus in sputum and tracheal aspirate is considered insufficient evidence to support CAPA diagnosis, but warrants further diagnostics through bronchoscopy and BAL Strong Low
We recommend maximum efforts to perform a bronchoscopy for inspection of the airways and bronchoalveolar lavage (BAL) to diagnose CAPA in patients with proven or high likelihood of COVID-19 in the ICU Strong Low
There is no recommendation against or in favor of using lateral flow devices-based assays for diagnosing CAPA Weak Very low