Table 2.
Effects of SNPs in genes encoding OCM-related enzymes on Hcy levels in patients with epilepsy.
| Gene | SNPs | Serum Hcy (μmol/l) | P-value | ||
|---|---|---|---|---|---|
| wild type | Heterozygotes | Homozygotes | |||
| GCPII | rs202676 | 13.18 ± 5.67 (AA: n = 137) | 13.15 ± 6.79 (AG: n = 116) | 13.17 ± 4.52 (GG: n = 24) | 0.999 |
| FOLR1 | rs2071010 | 13.69 ± 7.13 (GG: n = 188) | 12.1 ± 3.47 (GA: n = 83) | 15.04 ± 6.42 (AA: n = 8) | 0.112 |
| FOLR2 | rs2298444 | 13.91 ± 7.46 (TT: n = 105) | 12.93 ± 5.80 (TC: n = 129) | 12.67 ± 4.26 (CC: n = 45) | 0.392 |
| SLC19A1 | rs1051266 | 13.06 ± 5.67 (TT: n = 80) | 13.53 ± 5.69 (TC: n = 129) | 12.7 ± 8.18 (CC: n = 62) | 0.676 |
| rs914238 | 13.13 ± 6.73 (TT: n = 89) | 13.55 ± 6.26 (TC: n = 137) | 12.64 ± 5.62 (CC: n = 51) | 0.665 | |
| DHFR | rs380691 | 13.26 ± 6.22 (GG: n = 99) | 13.48 ± 6.53 (GA: n = 127) | 12.75 ± 5.95 (AA: n = 51) | 0.786 |
| MTHFD1 | rs1950902 | 13.17 ± 6.89 (GG: n = 115) | 13.36 ± 5.72 (GA: n = 125) | 13.12 ± 6.36 (AA: n = 38) | 0.965 |
| rs2236225 | 13.26 ± 6.85 (GG: n = 166) | 13.22 ± 5.31 (GA: n = 100) | 13.24 ± 6.5 (AA: n = 10) | 0.999 | |
| MTHFR | rs1801131 | 13.75 ± 6.87 (TT: n = 159) | 12.88 ± 5.6 (TG: n = 101) | 11.48 ± 3.94 (GG: n = 15) | 0.289 |
| rs1801133 | 12.4 ± 5.01 (CC: n = 156)b | 13.44 ± 4.79 (CT: n = 106)c | 19.92 ± 15.39 (TT: n = 17) | <0.001a | |
| TCN2 | rs1801198 | 13.37 ± 6.83 (GG: n = 95) | 12.63 ± 4.21 (GC: n = 131) | 14.53 ± 8.97 (CC: n = 52) | 0.177 |
| MTRR | rs1801394 | 12.88 ± 6.4 (AA: n = 147) | 13.63 ± 6.21 (AG: n = 103) | 14.62 ± 7.05 (GG: n = 19) | 0.425 |
| BHMT | rs3733890 | 12.59 ± 6.21 (GG: n = 131) | 13.78 ± 6.61 (GA: n = 118) | 13.80 ± 4.81 (AA: n = 26) | 0.29 |
| DNMT1 | rs2114724 | 13.6 ± 6.49 (CC: n = 143) | 12.93 ± 6.49 (CT: n = 107) | 12.65 ± 4.17 (TT: n = 28) | 0.615 |
| rs2241531 | 12.92 ± 6.22 (CC: n = 83) | 12.87 ± 5.18 (CG: n = 139) | 14.79 ± 8.52 (GG: n = 55) | 0.134 | |
| rs7253062 | 13.67 ± 6.77 (GG: n = 143) | 12.84 ± 5.84 (GA: n = 119) | 13.2 ± 5.21 (AA: n = 14) | 0.576 | |
| DNMT3a | rs13036246 | 13 ± 5.44 (CC: n = 143) | 14.02 ± 7.54 (CT: n = 110) | 11.5 ± 4.12 (TT: n = 25) | 0.149 |
| rs34048824 | 13.07 ± 5.65 (TT: n = 168) | 13.83 ± 7.46 (TC: n = 97) | 11.54 ± 4.1 (CC: n = 14) | 0.368 | |
| rs6722613 | 13.14 ± 5.71 (GG: n = 113) | 13.51 ± 6.8 (GA: n = 128) | 12.79 ± 6.24 (AA: n = 37) | 0.796 | |
| rs7575625 | 13.12 ± 5.72 (AA: n = 160) | 13.6 ± 7.25 (AG: n = 106) | 12.09 ± 4.02 (GG: n = 13) | 0.662 | |
| rs7587636 | 13.14 ± 5.78 (GG: n = 119) | 13.62 ± 7.02 (GA: n = 133) | 11.98 ± 4.16 (AA: n = 27) | 0.452 | |
| DNMT3b | rs2424908 | 12.88 ± 4.83 (TT: n = 96) | 13.45 ± 6.61 (TC: n = 138) | 13.46 ± 7.89 (CC: n = 45) | 0.776 |
| rs6141813 | 13.17 ± 5.7 (AA: n = 116) | 13.15 ± 5.99 (AG: n = 130) | 14.11 ± 9.07 (GG: n = 32) | 0.722 | |
a
Serum Hcy levels were significantly different among groups.
b
TT vs. CC: 19.92 ± 15.39 vs. 12.4 ± 5.01 μmol/l, P < 0.001.
c
TT vs. CT: 19.92 ± 15.39 vs. 13.44 ± 4.79 μmol/l, P < 0.001.
P-values were calculated using ANOVA.
SNPs, some single nucleotide polymorphisms; Hcy, homocysteine.