Table 2.

Relationship between DACQ total score and PROs over the 12-month observation period (repeated measures regression model for numeric variables)

Effect	Estimate (β)	Standard error	Pr > |t|
B-IPQ score	−0.3135	0.04224	<0.0001
MMAS-4 score	1.7239	0.4693	0.0003
TSQM-9 effectiveness score	0.06700	0.03021	0.0270
TSQM-9 convenience score	0.1275	0.03289	0.0001
TSQM-9 global satisfaction score	0.09590	0.03270	0.0035

Only patients with information on the investigated parameters available at both enrollment and 12-month follow-up were included in the model (N= 244). CAT and mMRC scores were not included in the model because they were both highly correlated to B-IPQ scores (Spearman's correlation coefficients >0.65 and >0.55, respectively; p < 0.0001 in both cases).