Table 2.
Univariate and multivariable analyses to identify factors predicting PHLF grade B-C.
| Variables | Univariate logistic regression | Multivariable logistic regression | ||||
|---|---|---|---|---|---|---|
| β | Odds ratio | P value | β | Odds ratio | P value | |
| Age (years) | 0.024 | 1.025 | 0.056 | |||
| Sex (male) | 0.365 | 1.440 | 0.365 | |||
| Serum ALP (IU/L) | <0.001 | 1.000 | 0.894 | |||
| Serum γ-GGT (IU/L) | 0.001 | 1.001 | 0.069 | |||
| Positive HBsAg | −0.224 | 0.783 | 0.493 | |||
| Cirrhosis | 1.118 | 3.060 | <0.001 | 0.831 | 2.296 | 0.026 |
| Major hepatectomy | 0.795 | 2.214 | 0.005 | 0.794 | 2.211 | 0.031 |
| AFP (>400 ng/mL) | 0.005 | 1.005 | 0.986 | |||
| Tumour size (>5 cm) | 0.512 | 1.688 | 0.073 | |||
| Tumour number (multiple) | 0.920 | 2.508 | 0.003 | 0.649 | 1.913 | 0.090 |
| Ascites | 1.420 | 4.138 | 0.001 | 1.278 | 3.588 | 0.014 |
| Intraoperative blood loss (>400 mL) | 1.355 | 3.878 | <0.001 | 1.544 | 4.683 | <0.001 |
| PALBI score (>−2.53) | 2.081 | 8.015 | <0.001 | 1.283 | 3.609 | 0.005 |
| FIB-4 score (≥1.45) | 2.104 | 8.201 | <0.001 | 1.661 | 2.077 | <0.001 |
Abbreviations: ALP, alkaline phosphatase; γ-GGT, γ-glutamyl transpeptidase; HbsAg, hepatitis B surface antigen; AFP, alpha fetoprotein; PALBI, platelet-albumin-bilirubin; FIB-4, fibrosis-4 index.