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. Author manuscript; available in PMC: 2021 Sep 14.
Published in final edited form as: ACS Biomater Sci Eng. 2020 Aug 28;6(9):5084–5095. doi: 10.1021/acsbiomaterials.0c00960

Figure 4.

Figure 4.

In vivo retention of peptide-functionalized PEG-4MAL nano-composite microgels. A) Rats received MMT surgery in the left joint, and 21 days after OA induction, were injected bilaterally with Cy7, WYR- or HAP-1-functionalized PEG-4MAL microgels. B) IVIS images of healthy and OA rat knees show that free Cy7 dye is cleared from the joints faster that nano-composite microgels. C) Radiant efficiency of the different formulations as a function on time (Mean ± SD, n=9). D) Half-life time obtained from one-phase exponential decay curve fit shows that nano-composite PEG-4MAL microgels present a significantly higher retention time compared to free dye (Mean ± SD, n=9, *p<0.05 compared to dye in MMT joints, #p<0.05 compared to dye in healthy joints).