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. Author manuscript; available in PMC: 2021 Jun 23.
Published in final edited form as: Nature. 2021 Jan 18;591(7851):639–644. doi: 10.1038/s41586-021-03207-w

Extended Data Fig. 3 |. Persistent longitudinal changes in the phenotypic landscape of B cells in individuals recovered from COVID-19.

Extended Data Fig. 3 |

a, Global viSNE projection of pooled B cells for all participants pooled shown in background contour plots, with overlaid projections of concatenated controls, and convalescent participants at 1.3 and 6.2 months. b, viSNE projection of pooled B cells for all participants of B cell clusters identified by FlowSOM clustering. Column-scaled z-scores of median fluorescence intensity (MFI) as indicated by cluster and marker. c, Frequency of B cells from each group in FlowSOM clusters indicated. Each circle represents an individual control individual (n = 20) (grey), convalescent participant at 1.3-month post-infection (n = 41) (red) or convalescent participant at 6.2 months post-infection (n = 41) (green). Horizontal bars indicate mean values. Significance determined by two-tailed paired t-test for comparisons between time points within individuals and two-tailed unpaired t-test for comparison between controls and convalescent individuals. d, Individual viSNE projections of indicated protein expression.